Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations. One risk factor for …

Neuroinflammation is a common feature in neurodegenerative diseases, modulated by the
Alzheimer's disease risk factor, apolipoprotein E (APOE). In the brain, apoE protein is …

Apolipoprotein E (APOE) is the major cholesterol carrier in the brain, affecting various
normal cellular processes including neuronal growth, repair and remodeling of membranes …

One of the primary genetic risk factors for Alzheimer's disease (AD) is the presence of the Ɛ4
allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major …

The APOE ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease
(AD). ApoE protein aggregation plays a central role in AD pathology, including the …

The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease
(AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been …

Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

Apolipoprotein E transports lipids and couples metabolism between astrocytes and neurons.
The E4 variant (APOE4) affects these functions and represents a genetic predisposition for …

The deposition of amyloid-beta (Aβ) plaques in the brain is one of the primary pathological
characteristics of Alzheimer's disease (AD). It can take place 20–30 years before the onset of …