Rationale and objectives: Repeated exposure to many drugs of abuse results in a
progressive and enduring enhancement in the motor stimulant effect elicited by a …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

The effects of aging on glutamate neurotransmission in the brain is reviewed and evaluated.
Glutamate is the neurotransmitter in most of the excitatory synapses and appears to be …

The development of new treatments for substance use disorders requires identification of
targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in …

OBJECTIVE: Recent investigations of schizophrenia have targeted glutamatergic
neurotransmission, since phencyclidine, an N-methyl-d-aspartate (NMDA) receptor …

Amphetamines modify the brain and alter behavior through mechanisms generally attributed
to their ability to regulate extracellular dopamine concentrations. However, the actions of …

Four electrode materials: Pt, Au, Pd and glassy carbon (GC), were studied to investigate
their suitability as substrates in the development of two different classes of glutamate …

Objectives Modafinil is a waking drug prescribed to narcolepsy patients, but its usage
among healthy individuals is increasing to enhance their alertness or to mitigate fatigue …

J. Neurochem.(2010) 115, 1608–1620. Abstract Glutamate in the prefrontal cortex (PFC)
plays a significant role in several mental illnesses, including schizophrenia, addiction and …

Amphetamine is an indirect dopamine receptor agonist and increases glutamate release in
the striatum. Activation of group I metabotropic glutamate receptors (mGluRs) upregulates …