Cell-based chemical safety assessment and therapeutic discovery using array-based sensors

M Jiang, AN Chattopadhyay, VM Rotello - International Journal of …, 2022 - mdpi.com
Synthetic chemicals are widely used in food, agriculture, and medicine, making chemical
safety assessments necessary for environmental exposure. In addition, the rapid …

Nanomedomics

G Liang, W Cao, D Tang, H Zhang, Y Yu, J Ding… - ACS …, 2024 - ACS Publications
Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such
as inorganic, lipid, polymers, and protein nanoparticles have been widely developed for …

Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer

M Jiang, AN Chattopadhyay, CH Li, Y Geng… - Chemical …, 2022 - pubs.rsc.org
Cell surface glycans serve fundamental roles in many biological processes, including cell–
cell interaction, pathogen infection, and cancer metastasis. Cancer cell surface have …

[HTML][HTML] Nanosensor-enabled detection and identification of intracellular bacterial infections in macrophages

AN Chattopadhyay, M Jiang, JMV Makabenta, J Park… - Biosensors, 2024 - mdpi.com
Opportunistic bacterial pathogens can evade the immune response by residing and
reproducing within host immune cells, including macrophages. These intracellular infections …

Rapid Identification of Cell Types and Phenotypic States Using a One-Polymer Multichannel Nanosensor Fabricated via Flash Nanoprecipitation

M Jiang, J Yang, L Liu, AN Chattopadhyay… - … Applied Materials & …, 2024 - ACS Publications
Cell state transitions are fundamental in biology, determining how cells respond to
environmental stimuli and adapt to diseases and treatments. Cell surface-based sensing of …

High affinity protein surface binding through co-engineering of nanoparticles and proteins

M Ray, G Brancolini, DC Luther, Z Jiang, R Cao-Milán… - Nanoscale, 2022 - pubs.rsc.org
Control over supramolecular recognition between proteins and nanoparticles (NPs) is of
fundamental importance in therapeutic applications and sensor development. Most NP …

Sensor Array-Enabled Identification of Drugs for Repolarization of Macrophages to Anti-Inflammatory Phenotypes

M Jiang, AN Chattopadhyay, T Jeon, X Zhang… - Analytical …, 2023 - ACS Publications
Macrophages are key components of the innate immune system that have essential
functions in physiological processes and diseases. The phenotypic plasticity of …

Boronic acid-containing carbon dots array for sensitive identification of glycoproteins and cancer cells

S Chen, X Zhang, Y Yu, J Wang - Chinese Chemical Letters, 2021 - Elsevier
Discrimination of glycoproteins and cell types is a significant but difficult issue. Herein, we
presented a novel fluorescence sensor array for the detection and identification of …

[HTML][HTML] Polymer-Based Multichannel Sensor for Rapid Cell-Based Screening of Antibiotic Mechanisms and Resistance Development

SB Roy, A Nabawy, AN Chattopadhyay… - … applied materials & …, 2022 - ncbi.nlm.nih.gov
Antibiotic resistance presents a critical threat to public health, necessitating the rapid
development of novel antibiotics and appropriate choice of therapeutics to combat refractory …

Identification of Proteins Using Supramolecular Gold Nanoparticle‐Dye Sensor Arrays

M Jiang, A Gupta, X Zhang… - Analysis & …, 2023 - Wiley Online Library
The rapid detection of proteins is very important in the early diagnosis of diseases. Gold
nanoparticles (AuNPs) can be engineered to bind biomolecules efficiently and differentially …