Lipid nanoparticle-based strategies for extrahepatic delivery of nucleic acid therapies–challenges and opportunities
JB Simonsen - Journal of Controlled Release, 2024 - Elsevier
The advent of lipid nanoparticles (LNPs) containing ionizable cationic lipids has enabled the
encapsulation, stabilization, and intracellular delivery of nucleic acid payloads, leading to …
encapsulation, stabilization, and intracellular delivery of nucleic acid payloads, leading to …
Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia
For cystic fibrosis patients, a lung-targeted gene therapy would significantly alleviate
pulmonary complications associated with morbidity and mortality. However, mucus in the …
pulmonary complications associated with morbidity and mortality. However, mucus in the …
Pegylated solid lipid nanoparticles for the intranasal delivery of combination antiretroviral therapy composed of Atazanavir and Elvitegravir to treat NeuroAIDS
Intranasal drug administration offers a promising strategy for delivering combination
antiretroviral therapy (cART) directly to the central nervous system to treat NeuroAIDS …
antiretroviral therapy (cART) directly to the central nervous system to treat NeuroAIDS …
[HTML][HTML] Dual pH-responsive CRISPR/Cas9 ribonucleoprotein xenopeptide complexes for genome editing
X Luo, J Germer, T Burghardt, M Grau, Y Lin… - European Journal of …, 2025 - Elsevier
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR associated
(Cas) protein has been proved as a powerful tool for the treatment of genetic diseases. The …
(Cas) protein has been proved as a powerful tool for the treatment of genetic diseases. The …
Robust peptide/RNA complexes prepared with microfluidic mixing for pulmonary delivery by nebulisation
C Ma, MYT Chow, C Zhang, P Goldbaum… - Drug Delivery and …, 2025 - Springer
Small interfering RNA (siRNA) and messenger RNA (mRNA) have drawn considerable
attention in recent years due to their ability to modulate the expression of specific disease …
attention in recent years due to their ability to modulate the expression of specific disease …
Lipid Nanoparticle Delivery of miRNA-148a Counteracts Intestinal Injury during Experimental Necrotizing Enterocolitis
M Yeganeh - 2024 - utoronto.scholaris.ca
Necrotizing enterocolitis (NEC) is a gastrointestinal emergency in neonates, marked by
acute intestinal inflammation and necrosis. Milk-derived extracellular vesicles (EVs) prevent …
acute intestinal inflammation and necrosis. Milk-derived extracellular vesicles (EVs) prevent …
Lipid Nanoparticle Delivery of miRNA-148a Counteracts Intestinal Injury during Experimental Necrotizing Enterocolitis
MY Salman - 2024 - search.proquest.com
Necrotizing enterocolitis (NEC) is a gastrointestinal emergency in neonates, marked by
acute intestinal inflammation and necrosis. Milk-derived extracellular vesicles (EVs) prevent …
acute intestinal inflammation and necrosis. Milk-derived extracellular vesicles (EVs) prevent …