Context: Due to selection biases and inadequate statistical power, individual studies may fail
to identify the clinical features of patients with an aldosterone-producing adenoma (APA) …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Context Somatic mutations have been identified in more than half of aldosterone-producing
adenomas (APAs) through mutation hotspot sequencing. The underlying pathogenesis of …

Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in
genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent …

Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

Recent studies have shown that somatic mutations in the KCNJ5, ATP1A1, ATP2B3, and
CACNA1D genes are associated with the pathogenesis of aldosterone-producing adenoma …

The identification of several germline and somatic ion channel mutations in aldosterone-
producing adenomas (APAs) and detection of cell clusters that can be responsible for …

Aldosterone and cortisol, the main mineralocorticoid and glucocorticoid hormones in
humans, are produced in the adrenal cortex, which is composed of three concentric zones …

Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …

In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a
heterozygous point mutation in the selectivity filter of the stretch‐activated K2P potassium …