20 yr ago, a tribute appeared in this journal on the 70th anniversary of an animal model of
disseminated encephalomyelitis, abbreviated EAE for experimental autoimmune …

In this review article, we will first provide a brief overview of EGF receptor (EGFR) structure
and function, and its importance as a therapeutic target in epithelial carcinomas. We will …

Neuregulin‐1 and epidermal growth factor (EGF) are implicated in the pathogenesis of
schizophrenia. To test the developmental hypothesis for schizophrenia, we administered …

Background: Oncolytic viruses (OVs), which preferentially infect cancer cells and induce host
anti-tumor immune responses, have emerged as an effective melanoma therapy …

Neuregulin (NRG), an epidermal growth factor is known to promote the growth of various cell
types, including human melanoma cells through ErbB family of tyrosine kinases receptors …

Receptor tyrosine kinases (RTKs) are essential components of cell communication
pathways utilized from the embryonic to adult stages of life. These transmembrane receptors …

Matrix metalloproteinases (MMPs), which are involved in degradation of extracellular matrix,
are critical regulators in tumor progression, metastasis and angiogenesis. Although …

Insufficiency of standard cancer therapeutic agents and a high degree of toxicity associated
with chemotherapy and radiotherapy have created a dearth of therapeutic options for …

Oncolytic viruses (OVs) have emerged as a promising approach for melanoma treatment by
causing tumor lysis and inducing immuno-modulatory activities. Tanapoxvirus (TPV), which …

The signal molecule, Slit, is a family of secreted glycoprotein, which contains 3 isoforms,
Slit1-3. The cellular surface receptor for Slit is Robo (Roundabout), which contains 4 …