[HTML][HTML] The synaptic hypothesis of schizophrenia version III: a master mechanism
OD Howes, EC Onwordi - Molecular Psychiatry, 2023 - nature.com
The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …
approaches mean there has been a step-change in the evidence available, and some tenets …
The normative modeling framework for computational psychiatry
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …
differences at the level of a single subject or observation in relation to a reference model. It …
Evidence for embracing normative modeling
In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …
2022a to include normative models charting lifespan trajectories of structural surface area …
Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography
The understanding and treatment of psychiatric disorders, which are known to be
neurobiologically and clinically heterogeneous, could benefit from the data-driven …
neurobiologically and clinically heterogeneous, could benefit from the data-driven …
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Common risk factors for psychiatric and other brain disorders are likely to converge on
biological pathways influencing the development and maintenance of brain structure and …
biological pathways influencing the development and maintenance of brain structure and …
Charting brain growth and aging at high spatial precision
Defining reference models for population variation, and the ability to study individual
deviations is essential for understanding inter-individual variability and its relation to the …
deviations is essential for understanding inter-individual variability and its relation to the …
[HTML][HTML] Conceptualizing mental disorders as deviations from normative functioning
Normative models are a class of emerging statistical techniques useful for understanding the
heterogeneous biology underlying psychiatric disorders at the level of the individual …
heterogeneous biology underlying psychiatric disorders at the level of the individual …
Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning
Neurobiological heterogeneity in schizophrenia is poorly understood and confounds current
analyses. We investigated neuroanatomical subtypes in a multi-institutional multi-ethnic …
analyses. We investigated neuroanatomical subtypes in a multi-institutional multi-ethnic …
Common dysfunction of large-scale neurocognitive networks across psychiatric disorders
Background Cognitive dysfunction is one of the most prominent characteristics of psychiatric
disorders. Currently, the neural correlates of cognitive dysfunction across psychiatric …
disorders. Currently, the neural correlates of cognitive dysfunction across psychiatric …
Brain heterogeneity in schizophrenia and its association with polygenic risk
Importance Between-individual variability in brain structure is determined by gene-
environment interactions, possibly reflecting differential sensitivity to environmental and …
environment interactions, possibly reflecting differential sensitivity to environmental and …