tRNAs possess a high content of modified nucleosides, which display an incredible
structural variety. These modified nucleosides are conserved in their sequence and have …

Pteridines are aromatic compounds formed by fused pyrazine and pyrimidine rings. Many
living organisms synthesize pteridines, where they act as pigments, enzymatic cofactors, or …

Virtual screening can reduce costs and increase hit rates for lead discovery by eliminating
the need for robotics, reagent acquisition or production, and compound storage facilities …

The bacterial tRNA-guanine transglycosylase (TGT) is a tRNA modifying enzyme catalyzing
the exchange of guanine 34 by the modified base preQ1. The enzyme is involved in the …

In silico virtual screening for drug discovery has become a hot topic in medicinal chemistry
research during the last 5 years, growing from a largely academic pursuit concerned …

The enzyme tRNA-guanine transglycosylase (TGT) is involved in the pathogenicity of
Shigellae. As the crystal structure of this protein is known, it is a putative target for the …

The synthetic utility of pterins is often hampered by the notorious insolubility of this
heterocycle, slowing the development of medicinally relevant pteridine derivatives …

A case study should be considered before the numerous application examples are
presented in the last part of this book. Using the example of the tRNA-modifying enzyme …

Lead identification and optimisation have evolved into multidimensional, multidisciplinary
and information-driven processes. Herein, we review the contribution of computational …

A method for the preparation of 4-hydroxyquinoline-2, 3-dicarboxylates has been developed
by aza-Michael addition reaction of N-(2-aminobenzoyl) benzotriazoles with dimethyl …