Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

Covering: 2011–July 2016 Myxobacteria are a rich source for structurally diverse secondary
metabolites with intriguing biological activities. Here we report on new natural products that …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins interact with
the eukaryotic translation machinery, and inhibitors of translation have potent antiviral …

Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Microorganisms have been extensively applied as active biotherapeutic agents or drug
delivery vehicles for antitumor treatment because of their unparalleled bio-functionalities …

In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair
with specific decoding factors to decipher the mRNA code on ribosomes. We present …

Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis
of natural products. We underscored these achievements in a report published in …

Ribosomes frequently stall during mRNA translation, resulting in the context-dependent
activation of quality control pathways to maintain proteostasis. However, surveillance …

Conspectus The need for new drugs for the treatment of various diseases is enormous. From
the previous century until the present, numerous peptide and peptide-derived natural …

Enzymes are powerful catalysts for site-selective C–H bond functionalization. Identifying
suitable enzymes for this task and for biocatalysis in general remains challenging, however …