The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …

Diabetes mellitus (DM) is a growing health concern in society. Type 1 and type 2 DM are the
two main types of diabetes; both types are chronic diseases that affect glucose metabolism …

The liver plays a unique role in controlling carbohydrate metabolism by maintaining glucose
concentrations in a normal range over both short and long periods of times. In type 2 …

The glucokinase (GCK) gene was one of the first candidate genes to be identified as a
human “diabetes gene". Subsequently, important advances were made in understanding the …

Conversion of glucose into glycogen is a major pathway that contributes to the removal of
glucose from the portal vein by the liver in the postprandial state. It is regulated in part by the …

Although the general pathways of glycogen synthesis and glycogenolysis are identical in all
tissues, the enzymes involved are uniquely adapted to the specific role of glycogen in …

Hepatic glycogen is replenished during the absorptive period postprandially. This repletion
is prompted partly by an increased hepatic uptake of glucose by the liver, partly by …

Metabolic control analysis (MCA) provides a quantitative description of substrate flux in
response to changes in system parameters of complex enzyme systems. Medical …

A potentially important new drug for treating type 2 diabetes, tagatose, is now in phase 3
clinical trial. The history, development, additional health benefits, mechanisms of action and …

Obesity-associated insulin resistance (IR) is a major risk factor for developing type 2
diabetes and an array of other metabolic disorders. In particular, hepatic IR contributes to the …