The cell biology of the retinal pigment epithelium

A Lakkaraju, A Umapathy, LX Tan, L Daniele… - Progress in retinal and …, 2020 - Elsevier
The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: molecular mechanisms and relation to retinal inflammation

SA Lieffrig, G Gyimesi, Y Mao… - Immunological …, 2023 - Wiley Online Library
Mammalian photoreceptor outer segment renewal is a highly coordinated process that
hinges on timed cell signaling between photoreceptor neurons and the adjacent retinal …

Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina

LX Tan, CJ Germer, T Thamban, N La Cunza… - Current Biology, 2023 - cell.com
Balancing the competing demands of phagolysosomal degradation and autophagy is a
significant challenge for phagocytic tissues. Yet how this plasticity is accomplished in health …

Biochemistry and physiology of zebrafish photoreceptors

J Zang, SCF Neuhauss - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
All vertebrates share a canonical retina with light-sensitive photoreceptors in the outer
retina. These photoreceptors are of two kinds: rods and cones, adapted to low and bright …

Phosphoregulation of kinesins involved in long-range intracellular transport

D Kumari, K Ray - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of
intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions …

A novel quantification method for retinal pigment epithelium phagocytosis using a very-long-chain polyunsaturated fatty acids-based strategy

F Gao, E Tom, SA Lieffrig, SC Finnemann… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction The vertebrate retinal pigment epithelium (RPE) lies adjacent to the
photoreceptors and is responsible for the engulfment and degradation of shed …

Ciliary kinesins beyond IFT: cilium length, disassembly, cargo transport and signalling

ML Reilly, A Benmerah - Biology of the Cell, 2019 - Wiley Online Library
Cilia and flagella are microtubule‐based antenna which are highly conserved among
eukaryotes. In vertebrates, primary and motile cilia have evolved to exert several key …

Intraflagellar transport: A critical player in photoreceptor development and the pathogenesis of retinal degenerative diseases

M Gupta, GJ Pazour - Cytoskeleton, 2024 - Wiley Online Library
In vertebrate vision, photons are detected by highly specialized sensory cilia called outer
segments. Photoreceptor outer segments form by remodeling the membrane of a primary …

Probing photoreceptor outer segment phagocytosis by the RPE in vivo: models and methodologies

JA Vargas, SC Finnemann - International Journal of Molecular Sciences, 2022 - mdpi.com
In the vertebrate retina, the light-sensitive photoreceptor rods and cones constantly undergo
renewal by generating new portions of the outer segment and shedding their distal, spent …

Regulation of the rhythmic diversity of daily photoreceptor outer segment phagocytosis in vivo

AL Moran, JD Fehilly, D Floss Jones… - The FASEB …, 2022 - Wiley Online Library
Outer segment phagocytosis (OSP) is a highly‐regulated, biological process wherein
photoreceptor outer segment (OS) tips are cyclically phagocytosed by the adjacent retinal …