Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

The cancer secretome comprises factors secreted by tumors, including cytokines, growth
factors, proteins from the extracellular matrix (ECM), proteases and protease inhibitors …

Bacterial infection commonly complicates inflammatory airway diseases such as chronic
obstructive pulmonary disease (COPD). The mechanisms of increased infection …

Inflammation is implicated in triple negative breast cancer (TNBC) progression. TNBC
carries a worse prognosis than other breast cancer subtypes, and with the clinical and …

Background Triple-negative breast cancer (TNBC) treatment is currently restricted to
chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic …

In keeping with recent developments in basic research; the importance of the Cathepsins as
targets in cancer therapy have taken on increasing importance and given rise to a number of …

Background Triple negative breast cancer (TNBC) easily develops resistance to the first-line
drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein …

Gliomas encompass highly invasive primary central nervous system (CNS) tumours of glial
cell origin with an often-poor clinical prognosis. Of all gliomas, glioblastoma is the most …

Objective: Cathepsin D (CTSD) is a pivotal orchestrator in the occurrence and development
of tumors. Recently, CTSD was detected in salivary adenoid cystic carcinoma (SACC) …

Fracture healing is characterized by an inflammatory phase directly after fracture which has
a strong impact on the healing outcome. Neutrophils are strong contributors here and can …