Biosensors based on mechanical and electrical detection techniques

T Chalklen, Q Jing, S Kar-Narayan - Sensors, 2020 - mdpi.com
Biosensors are powerful analytical tools for biology and biomedicine, with applications
ranging from drug discovery to medical diagnostics, food safety, and agricultural and …

On the use of surface plasmon resonance biosensing to understand IgG-FcγR interactions

C Forest-Nault, J Gaudreault, O Henry… - International Journal of …, 2021 - mdpi.com
Surface plasmon resonance (SPR)-based optical biosensors offer real-time and label-free
analysis of protein interactions, which has extensively contributed to the discovery and …

Structural basis for broad HIV-1 neutralization by the MPER-specific human broadly neutralizing antibody LN01

D Pinto, C Fenwick, C Caillat, C Silacci, S Guseva… - Cell host & …, 2019 - cell.com
Potent and broadly neutralizing antibodies (bnAbs) are the hallmark of HIV-1 protection by
vaccination. The membrane-proximal external region (MPER) of the HIV-1 gp41 fusion …

[HTML][HTML] Parameter estimation and identifiability analysis for a bivalent analyte model of monoclonal antibody-antigen binding

K Nguyen, K Li, K Flores, GD Tomaras… - Analytical …, 2023 - Elsevier
Surface plasmon resonance (SPR) is an extensively used technique to characterize antigen-
antibody interactions. Affinity measurements by SPR typically involve testing the binding of …

Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies

C Xu, X Zhang, L Zhao, GM Verkhivker, F Bai - JACS Au, 2024 - ACS Publications
The binding kinetics of drugs to their targets are gradually being recognized as a crucial
indicator of the efficacy of drugs in vivo, leading to the development of various computational …

SPRD: a surface plasmon resonance database of common factors for better experimental planning

PB Tiwari, C Bencheqroun, M Lemus, T Shaw… - BMC molecular and cell …, 2021 - Springer
Background Surface plasmon resonance is a label-free biophysical technique that is widely
used in investigating biomolecular interactions, including protein-protein, protein-DNA, and …

Investigation of PAS and CNBH domain interactions in hERG channels and effects of long-QT syndrome-causing mutations with surface plasmon resonance

SM Soohoo, PB Tiwari, YJ Suzuki, TI Brelidze - Journal of Biological …, 2022 - ASBMB
Human ether-á-go-go-related gene (hERG) channels are key regulators of cardiac
repolarization, neuronal excitability, and tumorigenesis. hERG channels contain N-terminal …

Three-dimensional super-resolution fluorescence imaging of DNA

S Yardimci, DR Burnham, SYA Terry, H Yardimci - Scientific Reports, 2020 - nature.com
Recent advances in fluorescence super-resolution microscopy are providing important
insights into details of cellular structures. To acquire three dimensional (3D) super-resolution …

Note: Model identification and analysis of bivalent analyte surface plasmon resonance data

PB Tiwari, A Üren, J He, Y Darici… - Review of Scientific …, 2015 - pubs.aip.org
Surface plasmon resonance (SPR) is a widely used, affinity based, label-free biophysical
technique to investigate biomolecular interactions. The extraction of rate constants requires …

Isothermal titration calorimetry and surface plasmon resonance methods to probe protein–protein interactions

V Upadhyay, A Lucas, C Patrick, KMG Mallela - Methods, 2024 - Elsevier
Isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) are two
commonly used methods to probe biomolecular interactions. ITC can provide information …