Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …

During the last two decades, an increasing number of reports have pointed out that the
immunogenicity of polyethylene glycol (PEG) may trigger accelerated blood clearance …

Despite considerable progress in the design of multifunctionalized nanoparticles (NPs) that
selectively target specific cell types, their systemic application often results in unwanted liver …

T cells play an important role in immunity and repair and are implicated in diseases,
including blood cancers, viral infections, and inflammation, making them attractive targets for …

For decades, nanomedicines have been reported as a potential means to overcome the
limitations of conventional drug delivery systems by reducing side effects, toxicity and the …

Cancer stem-like cells (CSCs) play key roles in chemoresistance, tumor metastasis, and
clinical relapse. However, current CSC inhibitors lack specificity, efficacy, and applicability to …

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality, and
the efficacy of monotherapy for TNBC is still disappointing. Here, we developed a novel …

Immune responses are directed by the complex interactions of different cell types, including
T cells and Natural Killer (NK) cells, with a key type of interaction being the formation of …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, for which
no effective treatment is yet available to either slow or terminate it. Recent advances in gene …