Although absence of interleukin-7 (IL-7) signaling completely abrogates T and B
lymphopoiesis in mice, patients with severe combined immunodeficiency caused by …

WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations.
Here we report a decrease in bone mineral density in 25% of WHIM patients and bone …

Systemic inflammation halts lymphopoiesis and prioritizes myeloid cell production. How
blood cell production switches from homeostasis to emergency myelopoiesis is incompletely …

Both cell-intrinsic and niche-derived, cell-extrinsic cues drive the specification of
hematopoietic multipotent progenitors (MPPs) in the bone marrow, which comprise …

Acute lymphoblastic and myeloblastic leukemias (ALL and AML) have been known to modify
the bone marrow microenvironment and disrupt non-malignant hematopoiesis. However, the …

Fibroblasts are ubiquitous cells that can adopt many functional states. As tissue-resident
sentinels, they respond to acute damage signals and shape the earliest events in fibrotic …

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is an ultra-
rare combined primary immunodeficiency disease caused by heterozygous gain-of-function …

Aim WHIM (warts, hypogammaglobulinaemia, infections and myelokathexis) syndrome is a
rare combined primary immunodeficiency disease caused by gain‐of‐function (GOF) …

B-lymphocytopenia among myelosuppression is the most intractable side effect of
chemotherapy. Here, we investigated ways to alleviate 5-fluorouracil-caused stress …

Background WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis)
syndrome is an ultra-rare, combined primary immunodeficiency and chronic neutropenic …