Synthetic biology has been instrumental in turning microbes into cell-factories capable of
diverse processes. A recent application has been to convert them into living therapeutics …

Dynamic control of enzyme expression can be an effective strategy to engineer robust
metabolic pathways. It allows a synthetic pathway to self-regulate in response to changes in …

Background The skin barrier acts as the first line of defense against constant exposure to
biological, microbial, physical, and chemical environmental stressors. Dynamic interplay …

A grand challenge in synthetic biology is to push the design of biomolecular circuits from
purely genetic constructs towards systems that interface different levels of the cellular …

A hallmark of the nonalcoholic fatty liver disease is the accumulation of lipids. We developed
a mathematical model of the hepatic lipid dynamics to simulate the fate of fatty acids in …

Streptococcus pneumoniae (Sp) is a commensal bacterium that normally resides on the
upper airway epithelium without causing infection. However, factors such as co-infection …

We review results concerning dynamics in a class of hybrid ordinary differential equations
which incorporates logical control to yield piecewise linear equations. These equations …

Cellular metabolism contains intricate arrays of feedback control loops. These are a key
mechanism by which cells adapt and survive environmental disturbances. Gene regulation …

One of the marvels of biology is the phenotypic plasticity of microorganisms. It allows them to
maintain high growth rates across conditions. Studies suggest that cells can express …

Bistable switches are widely used in synthetic biology to trigger cellular functions in
response to environmental signals. All bistable switches developed so far, however, control …