Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …

Nasal drug delivery has been employed as an alternate and convenient route for the
systemic availability of pharmaceuticals, particularly for potent therapeutics. This is owing to …

Nebulizers have a number of advantages for the delivery of inhaled pharmaceutical
aerosols, including the use of aqueous formulations and the ability to deliver process …

Purpose: The objective of this study was to develop a computational fluid dynamics (CFD)
model to predict the deposition, dissolution, clearance, and absorption of pharmaceutical …

CFD has emerged as a promising diagnostic tool for clinical trials, with tremendous
potential. However, for real clinical applications to be useful, overall statistical findings from …

Objectives Vocal fold granulomas are benign lesions of the larynx commonly caused by
gastroesophageal reflux, intubation, and phonotrauma. Current medical therapy includes …

Momentum transfer from nasal spray droplets to the surrounding gas may create droplet
cloud motion and influence nasal deposition patterns. The objective of this study was to …

The development of a CFD model, from initial geometry to experimentally validated results
with engineering insight, can be a time-consuming process that often requires several …

Background: Computational fluid dynamics (CFD) provides a powerful tool for developing
new high-efficiency aerosol delivery strategies, such as nose-to-lung (N2L) aerosol …

The human nose can expand either actively or passively to increase airflow. Nasal dilation
may alter drug delivery efficiencies in the nasal airway or olfactory region. However, the …