Repurposed drug studies on the primary prevention of SARS-CoV-2 infection during the pandemic: systematic review and meta-analysis

G Zhou, S Verweij, MJ Bijlsma… - BMJ open …, 2023 - bmjopenrespres.bmj.com
Objective Current evidence on the effectiveness of SARS-CoV-2 prophylaxis is inconclusive.
We aimed to systematically evaluate published studies on repurposed drugs for the …

An observational multi-centric COVID-19 sequelae study among health care workers

AK Shukla, S Atal, A Banerjee, R Jhaj… - The Lancet Regional …, 2023 - thelancet.com
Background India has seen more than 43 million confirmed cases of COVID-19 as of April
2022, with a recovery rate of 98.8%, resulting in a large section of the population including …

Observational designs for real-world evidence studies

SR Taur - Perspectives in Clinical Research, 2022 - journals.lww.com
In the era of evidence-based medicine, real-world evidence (RWE) studies have opened
avenues to utilize real-world data (RWD) effectively for improving clinical decision-making …

[HTML][HTML] Safety and tolerability of hydroxychloroquine in health care workers and first responders for the prevention of COVID-19: WHIP COVID-19 Study

JE McKinnon, DD Wang, M Zervos, M Saval… - International Journal of …, 2022 - Elsevier
Background Health care workers (HCW) are among the highest risk groups for acquisition of
COVID-19 because of occupational exposures. The WHIP COVID-19 Study aimed to …

Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 infection among healthcare workers: a prospective cohort study

A Rao, SK Veluswamy, BG Shankarappa… - Expert Review of Anti …, 2022 - Taylor & Francis
Background Hydroxychloroquine had attracted significant attention in the initial phases of
the COVID-19 pandemic but current recommendations do not support its use. However, the …

Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model

J Wang, X Jing, L Hua, Y Zheng, S Hu, J Xiao… - Frontiers in …, 2022 - frontiersin.org
Chloroquine was once thought to be a promising treatment for COVID-19 but it quickly failed
due to its inefficiency and association with increased mortality. Further, comorbidities such …

[HTML][HTML] Hydroxychloroquine pre-exposure prophylaxis for COVID-19 in healthcare workers from India: a meta-analysis

RB Stricker, MC Fesler - Journal of Infection and Public Health, 2021 - Elsevier
To date, the COVID-19 pandemic has resulted in more than 200 million cases of SARS-CoV-
2 infection and more than four million deaths world-wide. 1 Although novel COVID-19 …

Population Pharmacokinetics of Hydroxychloroquine Sulfate in Healthcare Workers, Given for Prophylaxis Against Coronavirus Disease 2019 (COVID‐19) in India

JP Raj, NJ Gogtay, A Pandey, AK Kakkar… - The Journal of …, 2022 - Wiley Online Library
Healthcare workers (HCWs) and frontline workers were recommended hydroxychloroquine
(HCQ) 400 mg twice a day on day 1, followed by 400 mg once weekly for the next 7 weeks …

A safer option to hydroxychloroquine in the chemoprophylaxis of COVID-19 in high-risk health-care workers: A randomized controlled, non-inferiority trial

A Chopra, PK Rao, RG Reddy, M Gundeti… - 2021 - osf.io
Objectives: Comparative study of Ashwagandha (Withania somnifera; WS) and
hydroxychloroquine (HCQ) for chemoprophylaxis against COVID-19 in actively engaged …

Role of statistics in the era of data science.

RL Karandikar - Current Science (00113891), 2021 - search.ebscohost.com
Statistics evolved as a science in an era when the amount of data available was small and
efforts were on to extract maximum information from them. Are the techniques developed …