Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

Virtual screening has played a significant role in the discovery of small molecule inhibitors of
therapeutic targets in last two decades. Various ligand and structure-based virtual screening …

Abnormal protein–membrane attachment is involved in deregulated cellular pathways and
in disease. Therefore, the possibility to modulate protein–membrane interactions represents …

The allosteric modulation of peripheral membrane proteins (PMPs) by targeting protein-
membrane interactions with drug-like molecules represents a new promising therapeutic …

Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets
for treatment for thrombotic disorders and thereby their inhibitors can serve as effective …

Vascular calcification (VC) is an important contributor and prognostic factor in the
pathogenesis of cardiovascular diseases. VC is an active process mediated by the release …

Whether identified through high throughput screening or in silico screening, and whether
target-based or phenotypic, sets of hits will contain chemical con artists. Such pan-assay …

The plasmatic von Willebrand factor (VWF) circulates in a compact form unable to bind
platelets. Upon shear stress, the VWF A1 domain is exposed, allowing VWF-binding to …

Despite extensive research in the field of thrombotic diseases, the prevention of blood clots
remains an important area of study. Therefore, the development of new anticoagulant drugs …

Colon adenocarcinoma is the third most commonly diagnosed cancer and the second
deadliest one. Metabolic reprogramming, described as an emerging hallmark of malignant …