Mitochondria as a novel target for cancer chemoprevention: emergence of mitochondrial-targeting agents

M Huang, CR Myers, Y Wang, M You - Cancer Prevention Research, 2021 - AACR
Cancer chemoprevention is the most effective approach to control cancer in the population.
Despite significant progress, chemoprevention has not been widely adopted because …

Mitochondrial metal ion transport in cell metabolism and disease

X Wang, P An, Z Gu, Y Luo, J Luo - International journal of molecular …, 2021 - mdpi.com
Mitochondria are vital to life and provide biological energy for other organelles and cell
physiological processes. On the mitochondrial double layer membrane, there are a variety of …

Voltage-gated potassium channel Kv1. 3 as a target in therapy of cancer

A Teisseyre, A Palko-Labuz, K Sroda-Pomianek… - Frontiers in …, 2019 - frontiersin.org
Voltage-gated potassium channel Kv1. 3 is an integral membrane protein, which is
selectively permeable for potassium ions and is activated upon a change of membrane …

[HTML][HTML] Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy

SK Rout, V Priya, A Setia, AK Mehata, S Mohan… - Biomedicine & …, 2022 - Elsevier
Mitochondria play a crucial part in the cell's ability to adapt to the changing
microenvironments and their dysfunction is associated with an extensive array of illnesses …

Mitochondrial K+ channels and their implications for disease mechanisms

V Checchetto, L Leanza, D De Stefani, R Rizzuto… - Pharmacology & …, 2021 - Elsevier
The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Implication of voltage-gated potassium channels in neoplastic cell proliferation

C Serrano-Novillo, J Capera, M Colomer-Molera… - Cancers, 2019 - mdpi.com
Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are
involved in controlling the resting potential and action potential duration in the heart and …

Potential mitochondrial ROS-mediated damage induced by chitosan nanoparticles bee venom-loaded on cancer cell lines

AG Kamel, S Sabet, A El-Shibiny - International Journal of Biological …, 2024 - Elsevier
Recently, numerous studies have confirmed the importance of chitosan nanoparticles (CNP)
as a viable drug delivery carrier for increasing the efficacy of anticancer drugs in cancer …

Mitochondrial Volume Regulation and Swelling Mechanisms in Cardiomyocytes

XR Chapa-Dubocq, KM Rodríguez-Graciani… - Antioxidants, 2023 - mdpi.com
Mitochondrion, known as the “powerhouse” of the cell, regulates ion homeostasis, redox
state, cell proliferation and differentiation, and lipid synthesis. The inner mitochondrial …

[HTML][HTML] Integrative analyses identified ion channel genes GJB2 and SCNN1B as prognostic biomarkers and therapeutic targets for lung adenocarcinoma

A Lu, Y Shi, Y Liu, J Lin, H Zhang, Y Guo, L Li, Z Lin… - Lung Cancer, 2021 - Elsevier
Objectives Abnormal expressions of ion channel genes are associated with the occurrence
and progression of tumors. At present, their roles in the carcinogenesis of lung …

Induction of Paraptotic Cell Death in Cancer Cells by Triptycene–Peptide Hybrids and the Revised Mechanism of Paraptosis II

M Nii, K Yamaguchi, T Tojo, N Narushima, S Aoki - Biochemistry, 2024 - ACS Publications
In previous work, we reported on iridium (III)(Ir (III)) complex-peptide hybrids as amphiphilic
conjugates (IPH-ACs) and triptycene-peptide hybrids as amphiphilic conjugates (TPH-ACs) …