This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the
history, achievements, and medical advancements made over the last 40 years in this …

Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …

Successful implantation requires synchronous development of embryo and endometrium.
Endometrial receptivity results from progesterone‐induced differentiation of endometrial …

STUDY QUESTION What is the effect of a combination of three antioxidants (Acetyl-L-
Carnitine, N-Acetyl-L-Cysteine and α-Lipoic Acid), present in IVF medium during mouse …

In vitro follicle growth and oocyte maturation still has a series of limitations, since not all
oocytes matured in vitro have the potential to develop in viable embryos. One of the factors …

The phenotype of the human embryo conceived through in vitro fertilization (IVF), that is its
morphology, developmental kinetics, physiology and metabolism, can be affected by …

STUDY QUESTION What is the effect of three antioxidants (acetyl-L-carnitine, N-acetyl-L-
cysteine and α-lipoic acid), when used individually and in combination, on mouse embryo …

The success of clinical IVF was initially compromised by sub-optimal culture conditions,
resulting in impaired embryo development (1–6) and a subsequent loss of viability …

Assisted reproductive technology (ART) has led to the birth of millions of babies. In cattle,
thousands of embryos are produced annually. However, since the introduction and …