Abstract Learning Objectives After completing this course, the reader will be able to:
Describe phenotypic and clinical features associated with neurofibromatosis 1. Identify …

Importance Neurofibromatosis type 1 (NF1) is a complex genetic disorder that is associated
with not only neurofibromas, but also an increased susceptibility to other neoplasms …

Historically, brainstem gliomas have been considered as a single entity. Since the
introduction of magnetic resonance (MR) imaging in the late 1980s, these tumors are now …

Neurofibromatosis type 1 (NF1) is one of the most common genetic tumor predisposition
syndrome, caused by mutations in the NF1. To date, few genotype-phenotype correlations …

Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary neurocutaneous
syndrome characterized by multi‐system involvement and an increased incidence of both …

Background Malignant peripheral nerve sheath tumors (MPNST) are very rare in the general
population and challenging to treat. A paucity of data exists regarding the incidence of …

Epilepsy is relatively uncommon in patients with Neurofibromatosis Type 1 (NF1) and
seizures are usually well controlled with antiepileptic treatment. However …

Introduction Neurofibromatosis type 1 (NF1) has an incidence of 1 in 2,000 to 3,000
individuals and in 15% is associated with optic pathway glioma (OPG). Given the variability …

Objective Neurofibromatosis type 1 is one of the most common autosomal dominant
diseases caused by heterozygous mutation in the NF1 gene. Wide spectrum of NF1-related …

Abstract Neurofibromatosis type 1 (NF1) is a genetic multisystem disorder. Clinicians must
be aware of the diverse clinical features of this disorder in order to provide optimal care for it …