Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Melatonin is a pleiotropic molecule with multiple functions in plants. Since the discovery of
melatonin in plants, numerous studies have provided insight into the biosynthesis …

Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

The epidemiological studies have indicated a possible oncostatic property of melatonin on
different types of tumors. Besides, experimental studies have documented that melatonin …

Cancer is the leading cause of mortality worldwide, accounting for almost 13% of deaths in
the world. Among the conventional cancer treatments, chemotherapy is most frequently …

Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

Abstract Melatonin (N-acetyl-5-methoxy-tryptamine), which is generally considered as
pleiotropic and multitasking molecule, secretes from pineal gland at night under normal light …

Fluorouracil (5‐FU) is one of the most commonly used chemotherapeutic agents in colon
cancer treatment, but has a narrow therapeutic index limited by its toxicity. Melatonin exerts …

Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt
mammalian target of rapamycin (mTOR) signalling pathway. However, the effectiveness of …