Highlights•Host immune responses play both protective and pathogenic roles in IAV and
CoV infections.•Synergy of adaptive and innate immunity is required for efficient control of …

Neural rosettes develop from the self-organization of differentiating human pluripotent stem
cells. This process mimics the emergence of the embryonic central nervous system …

Severe influenza infection has no effective treatment available. One of the key barriers to
developing host-directed therapy is a lack of reliable prognostic factors needed to guide …

Methods for time series prediction and classification of gene regulatory networks (GRNs)
from gene expression data have been treated separately so far. The recent emergence of …

Understanding the systems biology approaches for promoting the development of new
therapeutic drugs is attaining importance nowadays. The threat of COVID-19 outbreak …

Immunomics is a relatively new field of research which integrates the disciplines of
immunology, genomics, proteomics, transcriptomics and bioinformatics to characterize the …

Highlights•Large scale omics have created the basis for influenza systems biology.•Systems
genetics makes an important contribution to systems biology.•Experimental animal models …

Large-scale assays, such as microarrays, next-generation sequencing and various “omics”
technologies, have explored multiple aspects of the immune response following virus …

In the road for network medicine the newly emerged systems-level subpathway-based
analysis methods offer new disease genes, drug targets and network-based biomarkers. In …

In Systems Biology, the complex relationships between different entities in the cells are
modeled and analyzed using networks. Towards this aim, a rich variety of gene regulatory …