Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

The aggregation of amyloid-β (Aβ) on lipid bilayers has been implicated as a mechanism by
which Aβ exerts its toxicity in Alzheimer's disease (AD). Lipid bilayer thinning has been …

The interactions of amyloid peptides with cell membranes play an important role in
maintaining the integrity and functionality of cell membrane. A thorough molecular-level …

In several neurodegenerative diseases, cell toxicity can emerge from damage produced by
amyloid aggregates to lipid membranes. The details accounting for this damage are poorly …

Amyloid-β (Aβ) and human islet polypeptide (hIAPP) are the causative agents responsible
for Alzheimer's disease (AD) and type II diabetes (T2D), respectively. While numerous …

Accumulating evidence suggests that amyloid plaque-associated myelin lipid loss as a
result of elevated amyloid burden might also contribute to Alzheimer's disease. The amyloid …

Alzheimer's disease (AD) is one of the neurodegenerative diseases characterized by
cognitive dysfunction and behavioral impairment. Early diagnosis of AD serves as a viable …

The misfolding and aggregation of proteins and peptides into amyloid fibrils are believed to
be responsible for the dysfunction and death of neuron cells in many neurodegenerative …

Proteins associated with neurodegenerative diseases are highly pleiomorphic and may
adopt an all-α-helical fold in one environment, assemble into all-β-sheet or collapse into a …

Background Charge and hydrophobicity are key factors for the construction of bioactive
proteins on bio-substrates. Amyloid-beta (Aβ) is a biomarker of Alzheimer's disease and …