Exploitation of recombinant DNA and sequencing technologies has led to a new concept in
vaccination in which isolated epitopes, capable of stimulating a specific immune response …

HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …

SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations,
and may reduce the efficacy of current vaccines that target the spike glycoprotein of SARS …

COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease
is a virally encoded protein that is essential across a broad spectrum of coronaviruses with …

Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …

The scientific community is focused on developing antiviral therapies to mitigate the impacts
of the ongoing novel coronavirus disease 2019 (COVID-19) outbreak. This will be facilitated …

Large-scale analysis of cellular response to anticancer drugs typically focuses on variation
in potency (half-maximum inhibitory concentration,(IC50)), assuming that it is the most …

The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …

Background Use of raltegravir with optimum background therapy is effective and well
tolerated in treatment-experienced patients with multidrug-resistant HIV-1 infection. We …

Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …