The management of spasticity in adults

KPS Nair, J Marsden - Bmj, 2014 - bmj.com
Spasticity is a common disorder affecting people with long term neurological conditions such
as stroke, multiple sclerosis, and traumatic brain and spinal cord injuries. A systematic …

Regulation of the JAK/STAT signaling pathway in spinal cord injury: an updated review

X Guo, C Jiang, Z Chen, X Wang, F Hong… - Frontiers in …, 2023 - frontiersin.org
Cytokines are involved in neural homeostasis and pathological processes associated with
neuroinflammation after spinal cord injury (SCI). The biological effect of cytokines, including …

A first-in-human, phase I study of neural stem cell transplantation for chronic spinal cord injury

E Curtis, JR Martin, B Gabel, N Sidhu, TK Rzesiewicz… - Cell stem cell, 2018 - cell.com
We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566)
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …

Training an actor-critic reinforcement learning controller for arm movement using human-generated rewards

KM Jagodnik, PS Thomas… - … on Neural Systems …, 2017 - ieeexplore.ieee.org
Functional Electrical Stimulation (FES) employs neuroprostheses to apply electrical current
to the nerves and muscles of individuals paralyzed by spinal cord injury to restore voluntary …

Effects of percutaneously-implanted epidural stimulation on cardiovascular autonomic function and spasticity after complete spinal cord injury: a case report

AS Gorgey, J Goldsmith, A Alazzam… - Frontiers in …, 2023 - frontiersin.org
Importance There is a revived interest to explore spinal cord epidural stimulation (SCES) to
improve physical function after spinal cord injury (SCI). This case report highlights the …

Evidence of treating spasticity before it develops: a systematic review of spasticity outcomes in acute spinal cord injury interventional trials

A Stampas, M Hook, R Korupolu… - Therapeutic …, 2022 - journals.sagepub.com
Introduction: Spasticity is a common consequence of spinal cord injury (SCI), estimated to
affect up to 93% of people living with SCI in the community. Problematic spasticity affects …

Intrathecal baclofen infusion pumps in the treatment of spasticity: a retrospective cohort study in a Portuguese centre

PV Reis, CR Vieira, AC Midões… - Acta Médica …, 2019 - actamedicaportuguesa.com
Introduction: Spasticity is a complex problem in patients with neurological disorders and may
distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity with low …

Autophagy regulation combined with stem cell therapy for treatment of spinal cord injury

Y Shen, YP Wang, X Cheng, X Yang… - Neural Regeneration …, 2023 - journals.lww.com
Stem cells are a group of cells with unique self-renewal and differentiation abilities that have
great prospects in the repair of spinal cord injury. However, stem cell renewal and …

Assessment of quality of life in relation to spasticity severity and socio-demographic and clinical factors among patients with spinal cord injury

M Vural, EY Yalcinkaya, EC Celik… - The Journal of Spinal …, 2020 - Taylor & Francis
Objective: To assess the impact of spasticity severity as well as socio-demographic and
clinical factors on quality of life (QOL) and to identify factors predicting poor QOL among …

Chronic pain for rheumatological disorders: Pathophysiology, therapeutics and evidence

Y Chen, AM Nelson, SP Cohen - Joint bone spine, 2024 - Elsevier
Pain is the leading reason people seek orthopedic and rheumatological care. By definition,
most pain can be classified as nociceptive, or pain resulting from non-neural tissue injury or …