Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

The drive to eat is a component of appetite control, independent of the omnivorous habit of
humans, and separate from food choice, satiety and food reward. The drive forms part of the …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Objective The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide,
stimulates insulin secretion and efficiently suppresses food intake to reduce body weight. As …

Rett Syndrome (RTT) is an autism spectrum disorder caused by mutations in the X-linked
gene encoding methyl-CpG binding protein 2 (MeCP2). In order to map the neuroanatomic …

Obesity ensues from an imbalance between energy intake and expenditure that results from
gene–environment interactions, which favour a positive energy balance. A society that …

Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS).
Characterization of the mechanisms that underlie PWS-associated hyperphagia has been …

Glial cells have emerged as key players in the central control of energy balance and etiology
of obesity. Astrocytes play a central role in neural communication via the release of …

Obesity is one of the most prevalent health conditions in humans and companion animals
globally. It is associated with premature mortality, metabolic dysfunction, and multiple health …

Adiponectin is one of the most thoroughly studied adipocytokines. Low plasma levels of
adiponectin are found to associate with obesity, metabolic syndrome, diabetes and many …