Clinical value of consensus molecular subtypes in colorectal cancer: a systematic review and meta-analysis
S Ten Hoorn, TR de Back… - JNCI: Journal of the …, 2022 - academic.oup.com
Background The consensus molecular subtypes (CMSs) of colorectal cancer (CRC) capture
tumor heterogeneity at the gene-expression level. Currently, a restricted number of …
tumor heterogeneity at the gene-expression level. Currently, a restricted number of …
Molecular subtyping of colorectal cancer: Recent progress, new challenges and emerging opportunities
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide.
Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical …
Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical …
Molecular characterization of colorectal cancer related peritoneal metastatic disease
KJ Lenos, S Bach, L Ferreira Moreno… - Nature …, 2022 - nature.com
A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases
(PM) in the course of their disease. PMs are associated with a poor quality of life, significant …
(PM) in the course of their disease. PMs are associated with a poor quality of life, significant …
Multi-omics of 34 colorectal cancer cell lines-a resource for biomedical studies
KCG Berg, PW Eide, IA Eilertsen, B Johannessen… - Molecular cancer, 2017 - Springer
Background Colorectal cancer (CRC) cell lines are widely used pre-clinical model systems.
Comprehensive insights into their molecular characteristics may improve model selection for …
Comprehensive insights into their molecular characteristics may improve model selection for …
CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models
Colorectal cancers (CRCs) can be divided into four gene expression-based biologically
distinct consensus molecular subtypes (CMS). This classification provides a potential …
distinct consensus molecular subtypes (CMS). This classification provides a potential …
DeepCC: a novel deep learning-based framework for cancer molecular subtype classification
Molecular subtyping of cancer is a critical step towards more individualized therapy and
provides important biological insights into cancer heterogeneity. Although gene expression …
provides important biological insights into cancer heterogeneity. Although gene expression …
Colorectal cancer consensus molecular subtypes translated to preclinical models uncover potentially targetable cancer cell dependencies
Purpose: Response to standard oncologic treatment is limited in colorectal cancer. The gene
expression–based consensus molecular subtypes (CMS) provide a new paradigm for …
expression–based consensus molecular subtypes (CMS) provide a new paradigm for …
Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer
Colorectal cancer (CRC) is a heterogeneous disease and recent advances in subtype
classification have successfully stratified the disease using molecular profiling. The …
classification have successfully stratified the disease using molecular profiling. The …
Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models
JF Linnekamp, SR Hooff, PR Prasetyanti… - Cell Death & …, 2018 - nature.com
Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and
clinical perspective. Several distinct molecular entities, such as microsatellite instability …
clinical perspective. Several distinct molecular entities, such as microsatellite instability …
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Obesity is a strong risk factor for cancer progression, posing obesity-related cancer as one of
the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer …
the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer …