Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …

Although they are classically viewed as continuously recirculating through the lymphoid
organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most …

Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

The liver is a unique anatomical and immunological site in which antigen‐rich blood from
the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

Oxazolone colitis (OC) is an experimental colitis that has a histologic resemblance to human
ulcerative colitis. Here we show that IL-13 production is a significant pathologic factor in OC …

CD1d-restricted natural killer (NK) T cells are known to potently secrete T helper (Th) 1 and
Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional …

The T-cell biology of the liver is unlike that of any other organ. The local lymphocyte
population is enriched in natural killer (NK) and NKT cells, which might have crucial roles in …

Many characteristics distinguish CD1d-reactive natural killer T (NKT) cells that express the
invariant Vα14–Jα18 T-cell receptor (known here as Vα14 i T cells) from conventional T …

Natural killer T (NKT) cells recognize glycosphingolipids presented by CD1d molecules and
have been linked to defense against microbial infections. Previously defined foreign …