Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …

Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …

The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225
family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells …

Förster resonance energy transfer (FRET) is a widespread technology used to analyze and
quantify protein interactions in multiple settings. While FRET is traditionally measured by …

Host interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral
restriction factors. Of these, IFITM3 potently inhibits viruses that enter cells through acidic …

Background & Aims Functional cure is achieved by a limited number of patients with chronic
hepatitis B (CHB) after nucleotide analogue (s) and interferon treatment. It is urgent to …

Interferon-inducible transmembrane protein 3 (IFITM3) inhibits influenza virus infection by
blocking viral membrane fusion, but the exact mechanism remains elusive. Here, we …

Background African swine fever (ASF) is a lethal hemorrhagic disease affecting domestic
pigs resulting in up to 100% mortality rates caused by the ASF virus (ASFV). The locally …

African swine fever virus (ASFV) causes an acute, hemorrhagic, and highly contagious
disease in domestic swine, leading to significant economic losses to the global porcine …

Broad-spectrum antiviral activities of interferon-induced transmembrane proteins (IFITMs)
are primarily attributed to in vitro inhibition of viral entry. Here, we used an avian sarcoma …