Recent breakthroughs in neurobiology indicate that the time is ripe to understand how
cellular-level mechanisms are related to conscious experience. Here, we highlight the …

Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

There is as yet no consensus concerning the neural basis of perception and how it operates
at a mechanistic level. We found that Ca2+ activity in the apical dendrites of a subset of layer …

A basic feature of intelligent systems such as the cerebral cortex is the ability to freely
associate aspects of perceived experience with an internal representation of the world and …

Successful navigation through the world requires accurate estimation of one's own speed.
To derive this estimate, animals integrate visual speed gauged from optic flow and run …

The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the
mammalian neocortex and serves as a major building block for the cortical column. L5b …

Calcium imaging is emerging as a popular technique in neuroscience. A major reason is
that intracellular calcium transients are reflections of electrical events in neurons. For …

Computations in neocortical circuits are predominantly driven by synaptic integration of
excitatory glutamatergic and inhibitory GABAergic inputs. New optical, electrophysiological …

One fundamental feature of consciousness is that the contents of consciousness depend on
the state of consciousness. Here, we propose an answer to why this is so: both the state and …

The conventional view of dendritic function is that dendrites collect synaptic input and deliver
it to the soma. This view has been challenged in recent years by new results demonstrating …