Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities

GZ Réus, LM Manosso, J Quevedo… - … & Biobehavioral Reviews, 2023 - Elsevier
Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …

The blood microbiome and health: current evidence, controversies, and challenges

HS Cheng, SP Tan, DMK Wong, WLY Koo… - International Journal of …, 2023 - mdpi.com
Blood is conventionally thought to be sterile. However, emerging evidence on the blood
microbiome has started to challenge this notion. Recent reports have revealed the presence …

Systematic review of probiotics as an adjuvant treatment for psychiatric disorders

E Forth, B Buehner, A Storer, C Sgarbossa… - Frontiers in behavioral …, 2023 - frontiersin.org
Introduction Many psychiatric illnesses have been linked to the gut microbiome, with
supplements such as probiotics showing some efficacy in alleviating the symptoms of some …

Abnormal blood microbiota profiles are associated with inflammation and immune restoration in HIV/AIDS individuals

X Guo, Z Wang, M Qu, Y Guo, M Yu, W Hong, C Zhang… - Msystems, 2023 - Am Soc Microbiol
Although gut microbiota alteration and related blood microbe profiles in human
immunodeficiency virus (HIV)-infected individuals are associated with the disease …

[HTML][HTML] Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review

C Rust, S Malan-Muller, LL van den Heuvel… - Journal of …, 2023 - Elsevier
In this narrative review, we examine the association between gut dysbiosis,
neuroinflammation, and stress-linked disorders, including depression, anxiety, and post …

Metabolomics of major depressive disorder: A systematic review of clinical studies

LNFG Costa, BA Carneiro, GS Alves, DHL Silva… - Cureus, 2022 - pmc.ncbi.nlm.nih.gov
Although the understanding of the pathophysiology of major depressive disorder (MDD) has
advanced greatly, this has not been translated into improved outcomes. To date, no …

Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis

G Chen, S Zhou, Q Chen, M Liu, M Dong… - Frontiers in Molecular …, 2022 - frontiersin.org
Major depression (MD) is a severe mental illness that creates a heavy social burden, and
the potential molecular mechanisms remain largely unknown. Lots of research demonstrate …

Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

C Toader, N Dobrin, D Costea, LA Glavan… - International journal of …, 2024 - mdpi.com
Psychiatric disorders represent a primary source of disability worldwide, manifesting as
disturbances in individuals' cognitive processes, emotional regulation, and behavioral …

Young adults with major depression show altered microbiome

M Chen, P Wang, X Xie, Z Nie, S Xu, N Zhang, W Wang… - Neuroscience, 2023 - Elsevier
There is growing basic and clinical evidence that major depressive disorder (MDD) is
associated with gut microbiome alterations, but clinical studies have tended not to adjust for …

Identification of sex-specific plasma biomarkers using metabolomics for major depressive disorder in children and adolescents

Y Jiang, M Qin, T Teng, X Li, Y Yu, J Wang… - Frontiers in …, 2022 - frontiersin.org
Background Children and adolescents are at a high risk of major depressive disorder (MDD)
with known sex differences in epidemiology. However, there are currently no objective …