Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

The kidney is arguably the most important target of microvascular damage in diabetes. A
substantial proportion of individuals with diabetes will develop kidney disease owing to their …

La tarea de elaboración de GPC incluye la creación de herramientas educativas y
programas de implementación de las recomendaciones. Para su implementación, se …

The original KDIGO Clinical Practice Guideline for the Management of Blood Pressure in
Chronic Kidney Disease in the chronic kidney disease (CKD) population not receiving …

Since the first description of the association between chronic kidney disease and heart
disease, many epidemiological studies have confirmed and extended this finding. As …

Importance Lowering blood pressure (BP) is widely used to reduce vascular risk in
individuals with diabetes. Objective To determine the associations between BP–lowering …

Background Limited evidence suggests that multifactorial interventions for control of
glucose, blood pressure, and lipids reduce macrovascular complications and mortality in …

Chronic kidney disease (CKD) affects a 15% of Americans, and diabetic kidney disease
(DKD) is the most common cause of kidney failure. 1, 2 Although the incidence of diabetes …

Objective To assess the effect of antihypertensive treatment on mortality and cardiovascular
morbidity in people with diabetes mellitus, at different blood pressure levels. Design …

Background: Type 2 diabetes mellitus is associated with an increased risk of hypertension,
and cardiovascular and renal disease, and it has been recommended that management of …