During pregnancy, the maternal uterus and fetus form a special microenvironment at the
maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs) …

The decidua has been known as maternal uterine tissue, which plays essential roles in
protecting the embryo from being attacked by maternal immune cells and provides …

The endometrium is crucial for the perpetuation of human species. It is a complex and
dynamic tissue lining the inner wall of the uterus, regulated throughout a woman's life based …

The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms,
PR‐A and PR‐B, exerts a profound influence on uterine functions during early gestation. In …

The uterus plays an essential role in the reproductive health of women and controls critical
processes such as embryo implantation, placental development, parturition, and …

Background The human endometrium is a highly dynamic tissue whose function is mainly
regulated by the ovarian steroid hormones estradiol and progesterone. The serum levels of …

Progesterone's ability to maintain pregnancy in eutherian mammals highlighted this steroid
as the “hormone of pregnancy”. It was the unique “pro-gestational” bioactivity of …

Progesterone acts through the progesterone receptor to direct physiological adaption of the
uterus in preparation and completion of pregnancy. Genome-wide transcriptome and …

Infertility affects one in six couples, with in vitro fertilization (IVF) offering many the chance of
conception. Compared to the solitary oocyte produced during the natural menstrual cycle …

Context Poor uterine receptivity is one major factor leading to pregnancy loss and infertility.
Understanding the molecular events governing successful implantation is hence critical in …