Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

Following the completion of the Human Genome Project in 2003, research in oncology has
progressively focused on the sequencing of cancer genomes, with the aim of better …

Background Single nucleotide polymorphism (SNP) arrays for domestic cattle have
catalyzed the identification of genetic markers associated with complex traits for inclusion in …

It is increasingly appreciated that oncogenic transformation alters cellular metabolism to
facilitate cell proliferation, but less is known about the metabolic changes that promote …

In recent years, a substantial body of evidence has emerged demonstrating that purine and
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …

Metabolic diseases should always be considered when evaluating children presenting with
seizures. This is because many metabolic disorders are potentially treatable and seizure …

Cancer treatment is becoming more and more individually based as a result of the large
inter-individual differences that exist in treatment outcome and toxicity when patients are …

Introduction The fluoropyrimidines (FP)(5-Fluorouracil, capecitabine, and tegafur) are
commonly used anti-cancer drugs, but lead to moderate to severe toxicity in about 10–40 …

Imidazole dipeptides (ID), such as carnosine (β-alanyl-L-histidine), are compounds widely
distributed in excitable tissues of vertebrates. ID are also endowed of several biochemical …

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the
catabolism of the pyrimidine bases uracil, thymine and the antineoplastic agent 5 …