Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future

A Łoboda, J Dulak - Pharmacological Reports, 2020 - Springer
Background Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular
childhood disorder that causes progressive muscle weakness and degeneration and results …

Histological methods to assess skeletal muscle degeneration and regeneration in Duchenne muscular dystrophy

N Dubuisson, R Versele, C Planchon… - International journal of …, 2022 - mdpi.com
Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …

A cellular and molecular spatial atlas of dystrophic muscle

MJ Stec, Q Su, C Adler, L Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Asynchronous skeletal muscle degeneration/regeneration is a hallmark feature of Duchenne
muscular dystrophy (DMD); however, traditional-omics technologies that lack spatial context …

The multifaceted view of heart problem in Duchenne muscular dystrophy

U Florczyk-Soluch, K Polak, J Dulak - Cellular and Molecular Life Sciences, 2021 - Springer
Dystrophin is a large protein serving as local scaffolding repetitively bridging cytoskeleton
and the outside of striated muscle cell. As such dystrophin is a critical brick primarily in …

miR-378 influences muscle satellite cells and enhances adipogenic potential of fibro-adipogenic progenitors but does not affect muscle regeneration in the glycerol …

O Mucha, P Podkalicka, M Żukowska, E Pośpiech… - Scientific Reports, 2023 - nature.com
Skeletal muscle regeneration relies on the reciprocal interaction between many types of
cells. Regenerative capacity may be altered in different disorders. In our study, we …

[HTML][HTML] Sodium hydrosulfide moderately alleviates the hallmark symptoms of Duchenne muscular dystrophy in mdx mice

M Myszka, O Mucha, P Podkalicka… - European Journal of …, 2023 - Elsevier
Duchenne muscular dystrophy (DMD) is an incurable disease caused by mutations in the X-
linked DMD gene that encodes a structural muscle protein, dystrophin. This, in turn, leads to …

[HTML][HTML] Dysregulated autophagy and mitophagy in a mouse model of Duchenne muscular dystrophy remain unchanged following heme oxygenase-1 knockout

O Mucha, K Kaziród, P Podkalicka, K Rusin… - International journal of …, 2022 - mdpi.com
Dysregulation of autophagy may contribute to the progression of various muscle diseases,
including Duchenne muscular dystrophy (DMD). Heme oxygenase-1 (HO-1, encoded by …

miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy

P Podkalicka, O Mucha, K Kaziród, K Szade… - Scientific Reports, 2022 - nature.com
Although Duchenne muscular dystrophy (DMD) primarily affects muscle tissues, the
alterations to systemic metabolism manifested in DMD patients contribute to the severe …

Therapeutic aspects of cell signaling and communication in Duchenne muscular dystrophy

A Starosta, P Konieczny - Cellular and Molecular Life Sciences, 2021 - Springer
Duchenne muscular dystrophy (DMD) is a devastating chromosome X-linked disease that
manifests predominantly in progressive skeletal muscle wasting and dysfunctions in the …

Generation of microRNA-378a-deficient hiPSC as a novel tool to study its role in human cardiomyocytes

A Martyniak, K Andrysiak, B Motais, S Coste… - Journal of molecular and …, 2021 - Elsevier
Abstract microRNA-378a (miR-378a) is one of the most highly expressed microRNAs in the
heart. However, its role in the human cardiac tissue has not been fully understood. It was …