The immune response in tuberculosis

A O'Garra, PS Redford, FW McNab… - Annual review of …, 2013 - annualreviews.org
There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?

YM Jacobo-Delgado, A Rodríguez-Carlos… - Frontiers in …, 2023 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is one of the most important infectious agents worldwide
and causes more than 1.5 million deaths annually. To make matters worse, the drug …

Ability of Innate Defence Regulator Peptides IDR-1002, IDR-HH2 and IDR-1018 to Protect against Mycobacterium tuberculosis Infections in Animal Models

B Rivas-Santiago, JE Castañeda-Delgado… - PloS one, 2013 - journals.plos.org
Tuberculosis is an ongoing threat to global health, especially with the emergence of multi
drug-resistant (MDR) and extremely drug-resistant strains that are motivating the search for …

LL-37 immunomodulatory activity during Mycobacterium tuberculosis infection in macrophages

F Torres-Juarez, A Cardenas-Vargas… - Infection and …, 2015 - Am Soc Microbiol
Tuberculosis is one of the most important infectious diseases worldwide. The susceptibility
to this disease depends to a great extent on the innate immune response against …

Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis

B Rivas-Santiago, CER Santiago… - International journal of …, 2013 - Elsevier
Tuberculosis (TB) is a major worldwide health problem in part due to the lack of
development of new treatments and the emergence of new strains such as multidrug …

Evidence of an Antimicrobial-Immunomodulatory Role of Atlantic Salmon Cathelicidins during Infection with Yersinia ruckeri

A Bridle, E Nosworthy, M Polinski, B Nowak - PloS one, 2011 - journals.plos.org
Cathelicidins are a family of antimicrobial peptides that act as effector molecules of the
innate immune system with broad-spectrum antimicrobial properties. These evolutionary …

Increased risk of latent tuberculous infection among persons with pre-diabetes and diabetes mellitus

RL Hensel, RR Kempker, J Tapia… - … of Tuberculosis and …, 2016 - ingentaconnect.com
SETTING: Although diabetes mellitus (DM) is an established risk factor for active
tuberculosis (TB) disease, little is known about the association between pre-DM, DM, and …

Perspectives on host adaptation in response to Mycobacterium tuberculosis: modulation of inflammation

A Dorhoi, SHE Kaufmann - Seminars in immunology, 2014 - Elsevier
Tuberculosis (TB) is the outcome of an insidious, protracted infection with Mycobacterium
tuberculosis (Mtb). It primarily affects the lung and is characterized by extensive focal …

Immune vulnerability of infants to tuberculosis

K Vanden Driessche, A Persson… - Journal of …, 2013 - Wiley Online Library
One of the challenges faced by the infant immune system is learning to distinguish the
myriad of foreign but nonthreatening antigens encountered from those expressed by true …

Differential expression of antimicrobial peptides in active and latent tuberculosis and its relationship with diabetes mellitus

I Gonzalez-Curiel, J Castañeda-Delgado… - Human immunology, 2011 - Elsevier
Tuberculosis (TB) is one of the most important infectious diseases, causing 1.8 million
deaths annually worldwide. This problem has increased because of the association with …