Cell invasion through basement membrane barriers is crucial during many developmental
processes and in immune surveillance. Dysregulation of invasion also drives the pathology …

After decades of research, our knowledge of the complexity of cancer mechanisms,
elegantly summarized as 'hallmarks of cancer', is expanding, as are the therapeutic …

The auxin-inducible degradation system has been widely adopted in the Caenorhabditis
elegans research community for its ability to empirically control the spatiotemporal …

Cell invasion through basement membrane (BM) barriers is important in development,
immune function and cancer progression. As invasion through BM is often stochastic …

Site-specific histone modifications have long been recognized to play an important role in
directing gene transcription in chromatin in biology of health and disease. However …

Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing
incidence. Hereditary CM accounts for a significant percentage (5–15%) of all CM cases …

Cyclin-dependent kinase (CDK) sensors have facilitated investigations of the cell cycle in
living cells. These genetically encoded fluorescent biosensors change their subcellular …

SWItch/sucrose non-fermenting (SWI/SNF) complexes are a family of chromatin remodelers
that are conserved across eukaryotes. Mutations in subunits of SWI/SNF cause a multitude …

In the past decade, numerous epigenetic mechanisms have been discovered to be
associated with cancer. The mammalian SWI/SNF complex is an ATP-dependent chromatin …

Light sheet fluorescence microscopy (LSFM) has become a method of choice for live
imaging because of its fast acquisition and reduced photobleaching and phototoxicity …