Delivering on the promise of recombinant silk-inspired proteins for drug delivery

C Gonzalez-Obeso, EJ Hartzell, RA Scheel… - Advanced drug delivery …, 2023 - Elsevier
Effective drug delivery is essential for the success of a medical treatment. Polymeric drug
delivery systems (DDSs) are preferred over systemic administration of drugs due to their …

A review on advances in the applications of spider silk in biomedical issues

B Bakhshandeh, SS Nateghi, MM Gazani… - International Journal of …, 2021 - Elsevier
Spider silk, as one of the hardest natural and biocompatible substances with extraordinary
strength and flexibility, have become an ideal option in various areas of science and have …

Bioengineered elastin-and silk-biomaterials for drug and gene delivery

L Chambre, Z Martín-Moldes, RN Parker… - Advanced drug delivery …, 2020 - Elsevier
Advances in medical science have led to diverse new therapeutic modalities, as well as
enhanced understanding of the progression of various disease states. These findings …

3D‐Printed and Recombinant Spider Silk Particle Reinforced Collagen Composite Scaffolds for Soft Tissue Engineering

KS Koeck, VT Trossmann… - Advanced Functional …, 2024 - Wiley Online Library
Collagen is one main component of the extracellular matrix (ECM) in natural tissues and is,
therefore, well suited as a biomaterial for tissue engineering. In this study, a method is …

Silk particles as carriers of therapeutic molecules for cancer treatment

A Florczak, I Grzechowiak, T Deptuch, K Kucharczyk… - Materials, 2020 - mdpi.com
Although progress is observed in cancer treatment, this disease continues to be the second
leading cause of death worldwide. The current understanding of cancer indicates that …

Bioengineering of spider silks for the production of biomedical materials

DMC Bittencourt, P Oliveira… - … in Bioengineering and …, 2022 - frontiersin.org
Spider silks are well known for their extraordinary mechanical properties. This characteristic
is a result of the interplay of composition, structure and self-assembly of spider silk proteins …

Preparation and statistical characterization of tunable porous sponge scaffolds using UV cross-linking of methacrylate-modified silk fibroin

A Bucciarelli, T Muthukumar, JS Kim… - ACS biomaterials …, 2019 - ACS Publications
Silk fibroin sponges have been widely studied and reported in literature for tissue
engineering applications. Several fabrication methods have been proposed during the years …

Systemic and local silk-based drug delivery systems for cancer therapy

A Florczak, T Deptuch, K Kucharczyk… - Cancers, 2021 - mdpi.com
Simple Summary Application of drug delivery systems (DDS) in oncology may increase the
effectiveness of cancer treatment and reduce the associated adverse side effects. Although …

Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications

K Kucharczyk, JD Rybka, M Hilgendorff, M Krupinski… - PLoS …, 2019 - journals.plos.org
Bioengineered spider silk is a biomaterial that has exquisite mechanical properties,
biocompatibility, and biodegradability. Iron oxide nanoparticles can be applied for the …

Designed spider silk-based drug carrier for redox-or pH-triggered drug release

HM Herold, A Döbl, S Wohlrab, M Humenik… - …, 2020 - ACS Publications
Targeted drug delivery and controlled drug release can be obtained using specifically
designed polymers as carriers. Due to their biocompatibility and biodegradability and …