Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial
resistance, often consuming a large proportion of the healthcare budget and associated …

Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …

Interrupting transmission events is critical to tuberculosis control. Cough-generated aerosol
cultures predict tuberculosis transmission better than microbiological or clinical markers. We …

Background: Individuals with bacteriologically confirmed pulmonary tuberculosis (TB)
disease who do not report symptoms (subclinical TB) represent around half of all prevalent …

Background Sputum is the most widely used sample to diagnose active tuberculosis, but
many people living with HIV are unable to produce sputum. Urine, in contrast, is readily …

Tuberculosis has affected humankind for thousands of years, but a deeper understanding of
its cause and transmission only arose after Robert Koch discovered Mycobacterium …

Neuroimmune recognition and regulation in the respiratory system is a complex and highly
coordinated process involving interactions between the nervous and immune systems to …

The current active–latent paradigm of tuberculosis largely neglects the documented
spectrum of disease. Inconsistency with regard to definitions, terminology, and diagnostic …

Potential Mycobacterium tuberculosis (Mtb) transmission during different pulmonary
tuberculosis (TB) disease states is poorly understood. We quantified viable aerosolized Mtb …

Mycobacterium tuberculosis (M. tb) is a bacterial pathogen that has evolved in humans, and
its interactions with the host are complex and best studied in humans. Myriad immune …