The loss of regenerative capacity is the most dramatic age-associated alteration in the liver.
Although this phenomenon was reported over 50 years ago, the molecular basis for the loss …

The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …

The decline of tissue regenerative potential is a hallmark of ageing and may be due to age-
related changes in tissue-specific stem cells,,,,. A decline in skeletal muscle stem cell …

Transcription factors derived from CCAAT/enhancer binding protein (C/EBP) α and C/EBPβ
genes control differentiation and proliferation in a number of cell types. Various C/EBP …

The liver is capable of completely regenerating itself in response to injury and after partial
hepatectomy. In liver of old animals, the proliferative response is dramatically reduced, the …

Wnt signaling maintains preadipocytes in an undifferentiated state. When Wnt signaling is
enforced, 3T3-L1 preadipocytes no longer undergo adipocyte conversion in response to …

Using an inducible transcription system which allows the regulated expression of C/EBP
isoforms in tissue culture cells, we have found that the ectopic expression of C/EBPα, at a …

The transcription factor CCAAT/enhancer binding protein β, C/EBPβ, plays a significant role
in the regulation of hepatocyte growth and differentiation. A single mRNA coding for C/EBPβ …

The regenerative capacity of the liver is well known, and the mechanisms that regulate this
process have been extensively studied using experimental model systems including …

Aging increases the incidence of chronic liver disease (CLD), worsens its prognosis, and
represents the predominant risk factor for its development at all different stages. The hepatic …