The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …

Eosinophils have been considered end-stage cells involved in host protection against
parasites. However, numerous lines of evidence have now changed this perspective by …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …

Improved understanding of the contribution of eosinophils to various chronic inflammatory
conditions, most notably allergic asthma, has encouraged development of monoclonal …

The role of eosinophils as effector cells in asthma pathogenesis has been questioned since
an anti–interleukin (IL)-5 monoclonal antibody (mepolizumab), which depleted blood and …

IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the
airway mucosa would reduce airway inflammation. Forty-five patients with mild to moderate …

Blood eosinophilia and tissue eosinophilia are characteristic features of allergic
inflammation and asthma, conditions associated with prominent production of TH2 cytokines …

Antagonizing the effect of interleukin (IL)-5 is a potential new treatment strategy in allergic
disorders. We evaluated the safety, biological activity, and pharmacokinetics of SCH55700 …

While the vaginal ecosystem is maintained through mutualistic relationships between the
host and the vaginal bacteria, the effect of host genetics on the vaginal microbiota has not …

Over the years, the role of the eosinophil in asthma and allergic processes has been
disputed. Recent human experiments using a humanised monoclonal antibody to interleukin …