Progesterone-related immune modulation of pregnancy and labor

NM Shah, PF Lai, N Imami, MR Johnson - Frontiers in endocrinology, 2019 - frontiersin.org
Pregnancy involves a complex interplay between maternal neuroendocrine and
immunological systems in order to establish and sustain a growing fetus. It is thought that the …

The mechanical role of the cervix in pregnancy

KM Myers, H Feltovich, E Mazza, J Vink, M Bajka… - Journal of …, 2015 - Elsevier
Appropriate mechanical function of the uterine cervix is critical for maintaining a pregnancy
to term so that the fetus can develop fully. At the end of pregnancy, however, the cervix must …

Regulatory T cells play a role in a subset of idiopathic preterm labor/birth and adverse neonatal outcomes

N Gomez-Lopez, M Arenas-Hernandez, R Romero… - Cell reports, 2020 - cell.com
Regulatory T cells (Tregs) have been exhaustively investigated during early pregnancy;
however, their role later in gestation is poorly understood. Herein, we report that functional …

Prevention of preterm birth: harnessing science to address the global epidemic

CE Rubens, Y Sadovsky, L Muglia… - Science translational …, 2014 - science.org
Preterm birth is a leading cause of infant morbidity and mortality worldwide, but current
interventions to prevent prematurity are largely ineffective. Preterm birth is increasingly …

Vaginal progesterone vs cervical cerclage for the prevention of preterm birth in women with a sonographic short cervix, previous preterm birth, and singleton gestation …

A Conde-Agudelo, R Romero, K Nicolaides… - American journal of …, 2013 - Elsevier
OBJECTIVE: No randomized controlled trial has compared vaginal progesterone and
cervical cerclage directly for the prevention of preterm birth in women with a sonographic …

[PDF][PDF] Cervical remodeling in term and preterm birth: insights from an animal model

M Mahendroo - Reproduction, 2012 - scholar.archive.org
Proper cervical function is essential for a normal pregnancy and birth to occur.
Understanding the mechanisms that take place in normal pregnancy will allow a better …

Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways

MS Vidal Jr, RCV Lintao, MEL Severino… - Frontiers in …, 2022 - frontiersin.org
Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

A compact fiber-optic SHG scanning endomicroscope and its application to visualize cervical remodeling during pregnancy

Y Zhang, ML Akins, K Murari, J Xi… - Proceedings of the …, 2012 - National Acad Sciences
We report the development of an all-fiber-optic scanning endomicroscope capable of high-
resolution second harmonic generation (SHG) imaging of biological tissues and …

Myometrial immune cells contribute to term parturition, preterm labour and post‐partum involution in mice

O Shynlova, T Nedd‐Roderique, Y Li… - Journal of cellular …, 2013 - Wiley Online Library
This study aimed to determine the mechanism of uterine activation during labour, both term
(TL) and preterm (PTL). We hypothesized that the peripheral leucocytes are recruited to …

Next generation strategies for preventing preterm birth

HC Zierden, RL Shapiro, K DeLong, DM Carter… - Advanced drug delivery …, 2021 - Elsevier
Preterm birth (PTB) is defined as delivery before 37 weeks of gestation. Globally, 15 million
infants are born prematurely, putting these children at an increased risk of mortality and …