TCR-engineered T cell therapy in solid tumors: State of the art and perspectives
E Baulu, C Gardet, N Chuvin, S Depil - Science Advances, 2023 - science.org
T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …
T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
CA Klebanoff, SS Chandran, BM Baker… - Nature Reviews Drug …, 2023 - nature.com
The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
[HTML][HTML] T-cell repertoire analysis and metrics of diversity and clonality
J Chiffelle, R Genolet, MAS Perez, G Coukos… - Current opinion in …, 2020 - Elsevier
Highlights•Immune fitness in health and disease depends notably on the diversity of cellular
repertoires.•Single-cell sequencing is fostering the understanding of clonal diversity of T-cell …
repertoires.•Single-cell sequencing is fostering the understanding of clonal diversity of T-cell …
Can AlphaFold's breakthrough in protein structure help decode the fundamental principles of adaptive cellular immunity?
T cells are essential immune cells responsible for identifying and eliminating pathogens.
Through interactions between their T-cell antigen receptors (TCRs) and antigens presented …
Through interactions between their T-cell antigen receptors (TCRs) and antigens presented …
T cell epitope prediction and its application to immunotherapy
T cells play a crucial role in controlling and driving the immune response with their ability to
discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we …
discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we …
Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges
Z Pang, M Lu, Y Zhang, Y Gao, J Bai, J Gu, L Xie… - Biomarker …, 2023 - Springer
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising
approach for cancer therapy with an expectation of no significant side effects. In the human …
approach for cancer therapy with an expectation of no significant side effects. In the human …
Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning
Computational modelling of the interactions between T-cell receptors (TCRs) and epitopes
is of great importance for immunotherapy and antigen discovery. However, current TCR …
is of great importance for immunotherapy and antigen discovery. However, current TCR …
Predicting antigen specificity of single T cells based on TCR CDR 3 regions
It has recently become possible to simultaneously assay T‐cell specificity with respect to
large sets of antigens and the T‐cell receptor sequence in high‐throughput single‐cell …
large sets of antigens and the T‐cell receptor sequence in high‐throughput single‐cell …
An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants
Accurate predictive modeling of antibody-antigen complex structures and structure-based
antibody design remain major challenges in computational biology, with implications for …
antibody design remain major challenges in computational biology, with implications for …
Finding the ΔΔG spot: Are predictors of binding affinity changes upon mutations in protein–protein interactions ready for it?
Predicting the structure and thermodynamics of protein–protein interactions (PPIs) are key to
a proper understanding and modulation of their function. Since experimental methods might …
a proper understanding and modulation of their function. Since experimental methods might …