BTG2: a rising star of tumor suppressors

B Mao, Z Zhang, G Wang - International journal of …, 2014 - spandidos-publications.com
B-cell translocation gene 2 (BTG2), the first gene identified in the BTG/TOB gene family, is
involved in many biological activities in cancer cells acting as a tumor suppressor. The BTG2 …

TIS21 /BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule

IK Lim - Journal of cancer research and clinical oncology, 2006 - Springer
Abstract TIS21/BTG2/PC3, orthologs of mouse, human and rat, respectively, is initially
identified as one of the early growth response genes and induced by various stimulations …

Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization

I Goulet, G Gauvin, S Boisvenue, J Cote - Journal of Biological Chemistry, 2007 - ASBMB
PRMT1 is the predominant member of a family of protein arginine methyltransferases
(PRMTs) that have been implicated in various cellular processes, including transcription …

Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening

J Deng, Y Guo, F Yuan, S Chen, H Yin, X Jiang, F Jiao… - Autophagy, 2020 - Taylor & Francis
The mechanisms underlying glucocorticoid (GC)-increased adiposity are poorly understood.
Brown adipose tissue (BAT) acquires white adipose tissue (WAT) cell features defined as …

MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2)

H Jinghua, Z Qinghua, C Chenchen, C Lili, X Xiao… - …, 2021 - Taylor & Francis
MicroRNAs (miRNAs) dysregulation contributes to tumorigenesis, and it is reported that
abnormal miR-92a-3p expression participates in multiple cancers' occurrence and …

NUSAP1 knockdown inhibits cell growth and metastasis of non‐small‐cell lung cancer through regulating BTG2/PI3K/Akt signaling

ZY Xu, Y Wang, J Xiong, FX Cui… - Journal of Cellular …, 2020 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC) is the most common malignancy along with high
mortality rate worldwide. Recently, nucleolar and spindle‐associated protein 1 (NUSAP1) …

The BTG2 protein is a general activator of mRNA deadenylation

F Mauxion, C Faux, B Séraphin - The EMBO journal, 2008 - embopress.org
BTG2 is a prototype member of the BTG/Tob family of antiproliferative proteins, originally
identified as a primary response gene induced by growth factors and tumour promoters. Its …

BTG/TOB factors impact deadenylases

F Mauxion, CYA Chen, B Séraphin, AB Shyu - Trends in biochemical …, 2009 - cell.com
BTG/TOB factors are a family of antiproliferative proteins whose expression is altered in
numerous cancers. They have been implicated in cell differentiation, development and …

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

JC van Galen, RP Kuiper, L van Emst… - Blood, The Journal …, 2010 - ashpublications.org
Resistance to glucocorticoids (GCs) is a major clinical problem in the treatment of acute
lymphoblastic leukemia (ALL), but the underlying mechanisms are not well understood …

Influence of cell cycle on responses of MCF-7 cells to benzo [a] pyrene

H Hamouchene, VM Arlt, I Giddings, DH Phillips - BMC genomics, 2011 - Springer
Abstract Background Benzo [a] pyrene (BaP) is a widespread environmental genotoxic
carcinogen that damages DNA by forming adducts. This damage along with activation of the …