Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

A novel class of peptidomimetic foldamers based on diaza-peptide units are reported.
Circular dichroism, attenuated total reflection–Fourier transform infrared, NMR, and …

Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative disease and
remains a formidable global health challenge. The current medication for AD gives …

The islet amyloid polypeptide (IAPP), also known as amylin, is a hormone playing key
physiological roles. However, its aggregation and deposition in the pancreatic islets are …

In contrast to prevalent strategies which make use of β-sheet mimetics to block Aβ fibrillar
growth, in this study, we designed a series of sulfonyl-γ-AApeptide helices that targeted the …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is not restricted
to the neuronal compartment but includes important interactions with immune cells …

Loss of pancreatic β-cell mass is deleterious for type 2 diabetes patients since it reduces
insulin production, critical for glucose homeostasis. The main research axis developed over …

A “foldamer” is an artificial oligomeric molecule with a regular secondary or tertiary structure
consisting of various building blocks. A “stapled peptide” is a peptide with stabilized …

The extensive research work in the exhilarating area of foldamers (artificial oligomers
possessing well-defined conformation in solution) has shown them to be promising …