[HTML][HTML] Testing drug release from medicated contact lenses: The missing link to predict in vivo performance

AF Pereira-da-Mota, CM Phan, A Concheiro… - Journal of Controlled …, 2022 - Elsevier
Contact lenses (CLs) offer a wide variety of advantages as ocular drug-releasing platforms,
but the feasibility of medicated CL development is constrained by numerous scientific …

[HTML][HTML] Advances in chemistry and composition of soft materials for drug releasing contact lenses

S Chatterjee, P Upadhyay, M Mishra, M Srividya… - Rsc Advances, 2020 - pubs.rsc.org
Ocular drug delivery has always been a challenging feat to achieve in the field of medical
sciences. One of the existing methods of non-invasive ocular drug delivery is the use of eye …

Commercialization challenges for drug eluting contact lenses

OL Lanier, KG Christopher, RM Macoon… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Eye drops are commonly used for delivering ophthalmic drugs despite many
deficiencies including low bioavailability and poor compliance. Contact lenses can deliver …

[HTML][HTML] Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO …

DCT Nguyen, J Dowling, R Ryan, P McLoughlin… - Contact Lens and …, 2021 - Elsevier
Therapeutic contact lenses for ocular drug delivery have received considerable interest as
they can potentially enhance ocular bioavailability, increase patient compliance, and reduce …

A thermally and water activated shape memory gelatin physical hydrogel, with a gel point above the physiological temperature, for biomedical applications

RZ Alavijeh, P Shokrollahi, J Barzin - Journal of Materials Chemistry B, 2017 - pubs.rsc.org
In this study, a science based approach is taken to monitor the variation of the properties,
bioactivity and hydrogel formation behavior of gelatin upon functionalization with Ureido …

Chitosan/alginate based multilayers to control drug release from ophthalmic lens

D Silva, LFV Pinto, D Bozukova, LF Santos… - Colloids and surfaces B …, 2016 - Elsevier
In this study we investigated the possibility of using layer-by-layer deposition, based in
natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs …

Controlled release of antibiotics from vitamin E–loaded silicone-hydrogel contact lenses

P Paradiso, AP Serro, B Saramago, R Colaço… - Journal of …, 2016 - Elsevier
Symptoms of bacterial and fungal keratitis are typically treated through the frequent
application of antibiotic and antifungal eye drops. The high frequency of half hourly or hourly …

Sustained ophthalmic delivery of highly soluble drug using pH-triggered inner layer-embedded contact lens

Q Zhu, H Cheng, Y Huo, S Mao - International journal of pharmaceutics, 2018 - Elsevier
In the present work the feasibility of using inner layer-embedded contact lenses (CLs) to
achieve sustained release of highly water soluble drug, betaxolol hydrochloride (BH) on the …

Two-photon polymerization of hydrogels–versatile solutions to fabricate well-defined 3D structures

AI Ciuciu, PJ Cywiński - RSC Advances, 2014 - pubs.rsc.org
Hydrogels are cross-linked water-containing polymer networks that are formed by physical,
ionic or covalent interactions. In recent years, they have attracted significant attention …

[HTML][HTML] Resveratrol-loaded hydrogel contact lenses with antioxidant and antibiofilm performance

M Vivero-Lopez, A Muras, D Silva, AP Serro, A Otero… - Pharmaceutics, 2021 - mdpi.com
Contact lenses (CLs) are prone to biofilm formation, which may cause severe ocular
infections. Since the use of antibiotics is associated with resistance concerns, here, two …