Recent rapid progress in the field of mechanobiology has been driven by novel emerging
tools and methodologies and growing interest from different scientific disciplines. Specific …

Mechanosensitive (MS) ion channels are a common mechanism for perceiving and
responding to mechanical force. This class of mechanoreceptors is capable of transducing …

The conversion of mechanical force to chemical signals is critical for many biological
processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels …

While studying the physiological response of primary rat astrocytes to fluid shear stress in a
model of traumatic brain injury (TBI), we found that shear stress induced Ca2+ entry. The …

Members of the MscS superfamily of mechanosensitive ion channels function as osmotic
safety valves, releasing osmolytes under increased membrane tension. MscS homologs …

The rapid progress in mechanobiology has brought together many scientific and
engineering disciplines to work hand in hand toward better understanding of the role that …

In this article, a review of a series of applications of atomic force microscopy (AFM) and
fluidic Atomic Force Microscopy (fluidic AFM, hereafter fluidFM) in single‐cell studies is …

The force-from-lipid (FFL) principle states that it is the lateral stretch force from the lipid
membrane that ultimately opens mechanosensitive (MS) channels, not the external tether …

Mechanical stimuli acting on the cellular membrane are linked to intracellular signaling
events and downstream effectors via different mechanoreceptors. Mechanosensitive (MS) …

Main conclusion Mechanosensitive channels are integral membrane proteins that rapidly
translate extrinsic or intrinsic mechanical tensions into biological responses. They can serve …