Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Osteosarcoma, the most common malignant tumor of the bone, seriously influences people's
lives and increases their economic burden. Conventional chemotherapy drugs achieve …

Malignant tumors are one of the leading causes of death which impose an increasingly
heavy burden on all countries. Therefore, the establishment of research models that closely …

Osteosarcoma (OS) is the predominant primary bone tumor in the pediatric and adolescent
populations. It has high metastatic potential, with the lungs being the most common site of …

Bone is one of the key components of the musculoskeletal system. Bone and joint disease
are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

Signal transducer and activator of transcription (STAT) proteins compose a family of
transcription factors critical for cancer stem cells (CSCs), and they are involved in …

Uncontrolled growth and an enforced epithelial-mesenchymal transition (EMT) process
contribute to the poor survival rate of patients with osteosarcoma (OS). Long noncoding …